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 | Pancreatic cancer news
Chemoradiation for pancreatic cancer better
 The addition of the drug gemcitabine with chemoradiation for the therapy of patients who had surgery for pancreas cancer was linked to a survival benefit, eventhough this improvement was not statistically significant, as per a research studyin the March 5 issue of JAMA. Despite the potential benefits of surgically removing cancer involving the pancreas, there is a 50 percent to 85 percent rate of local relapse linked to liver and intra-abdominal failure and a 5-year survival of less than 20 percent, as per background information in the article. The frequency and pattern of failure makes the combination of added postoperative chemotherapy and radiation an important consideration. The drug gemcitabine has been shown to improve outcomes compared with the drug fluorouracil........
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| Wed, 05 Mar 2008 00:20:43 GMT
| The smaller the tumor, the better your chances
 The odds of surviving cancer of the pancreas increase dramatically for patients whose tumors are smallest, as per a new study by scientists at Saint Louis University and the M.D. Anderson Cancer Center in Houston the first study to specifically evaluate the link between tumor size and survival rates for one of the most common and deadly cancers........
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| Wed, 05 Mar 2008 00:20:43 GMT
| Pancreatic cancer cells evade immune system
 A protein that helps prevent a womans body from rejecting a fetus may also play an important role in enabling pancreas cancer cells to evade detection by the immune system, allowing them to spread in the body. Scientists at Jeffersons Kimmel Cancer Center in Philadelphia observed that the metastatic cancer cells in the lymph nodes of patients with pancreas cancer produce enough of the protein, IDO, to essentially wall-off the immune systems T-cells and recruit cells that suppress the immune systems response to the tumor. The findings might mean not only a better way to detect pancreas cancer spreading to lymph nodes, but also could enhance tumor immune treatment strategies against the fast-moving, deadly disease........
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| Wed, 05 Mar 2008 00:20:43 GMT
| Apple compounds reduce risk of pancreatic cancer
 Eating flavonol-rich foods like apples may help reduce the risk of pancreas cancer, says a team of international researchers. Quercetin, which is found naturally in apples and onions, has been identified as one of the most beneficial flavonols in preventing and reducing the risk of pancreas cancer. Eventhough the overall risk was reduced among the study participants, smokers who consumed foods rich in flavonols had a significantly greater risk reduction........
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| Wed, 05 Mar 2008 00:20:43 GMT
| Obesity, lack of exercise and pancreatic cancer
 Obesity and aversion to exercise have become hallmarks of modern society and a new study suggests that a blood protein associated with these lifestyle factors may be an indicator for an increased risk of developing pancreas cancer. Scientists from the Dana Farber Cancer Institute report their findings in the August 15 issue of Cancer Research, a journal of the American Association for Cancer Research........
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| Wed, 05 Mar 2008 00:20:43 GMT
| Protein May Indicate Pancreatic Cancer Risk
 A protein that dwindles in response to obesity and a sedentary lifestyle may one day help doctors predict which people are at increased risk for pancreas cancer, new research by Dana-Farber Cancer Institute and collaborating researchers indicates. In a report in the Aug. 15 issue of Cancer Research, the researchers observed that, in a large study group, people with the lowest blood levels of a protein called IGFBP-1 were twice as likely to develop pancreas cancer as those with higher levels. Though much work remains to determine if the protein -- whose acronym stands for insulin-like growth factor binding protein-1 -- is a reliable indicator of pancreas cancer risk, the finding adds to the scientific understanding of how the disease develops........
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| Wed, 05 Mar 2008 00:20:43 GMT
| New technique for earlier diagnosis of pancreatic cancer
 A new optical technology, coupled with routine endoscopy, may enable doctors to detect the subtle tell-tale traces of early pancreas cancer, as per scientists at Northwestern University in Illinois. The optical technology, developed by biomedical engineers at Northwestern exposes cellular changes indicative of cancer in tissue near the pancreas that had previously been detectable only through intensive radiologic scanning or invasive surgery, two techniques that can put pancreas cancer patients at risk........
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| Wed, 05 Mar 2008 00:20:43 GMT
| vitamin B6. B12 and folate, may decrease pancreatic cancer risk
 Scientists exploring the notion that certain nutrients might protect against pancreas cancer observed that lean individuals who got most of these nutrients from food were protected against developing cancer. The study also suggests this protective effect does not hold true if the nutrients come from vitamin supplements........
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| Wed, 05 Mar 2008 00:20:43 GMT
| A Pancreas Cancer Risk Model
 People with a family history of pancreatic cancer now have a way to accurately predict their chance of carrying a gene for hereditary pancreatic cancer and their lifetime risk of developing the disease. Developed by Johns Hopkins Kimmel Cancer Center researchers, the novel computer software tool is designed to help genetic counselors and physicians decide who would most benefit from early screening........
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| Wed, 05 Mar 2008 00:20:43 GMT
| Link Between Smoking AndPancreatic Cancer
 Scientists at Michigan State University have added yet another piece to the puzzle that links cigarette smoking with cancer of the pancreas, one of the deadliest forms of cancer. In research reported in the recent issue of the International Journal of Cancer, MSUs James Trosko and his colleagues zeroed in on the mechanism by which a healthy cell turns malignant........
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| Wed, 05 Mar 2008 00:20:43 GMT
| Pancreatic Cancer Surgery Five-Year Survivors
 A new study shows that pancreas cancer patients 65 or older who live at least five years after surgery have nearly as good a chance as anyone else to live another five years. Scientists at the Kimmel Cancer Center at Thomas Jefferson University and Thomas Jefferson University Hospital in Philadelphia evaluated the records of 890 patients with pancreas cancer who underwent the standard pancreaticoduodenectomy, or Whipple procedure, which entails the removal of the gallbladder, common bile duct, part of the duodenum, and the head of the pancreas, between 1970 and 1999 at Johns Hopkins University. They identified those who lived for five years, and compared those who lived for at least an additional five years to the "actuarial" - or estimated - survival of the general population beginning at age 70........
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| Wed, 05 Mar 2008 00:20:43 GMT
| Gene That Causes Familial Pancreatic Cancer
 An international group of scientists has discovered that the mutated form of a gene called Palladin causes familial pancreas cancer. The findings, published online today (Dec. 12) in the peer-evaluated journal PLoS-Medicine, may help explain why the disease is so deadly. The research project was led by Dr. Teri Brentnall, University of Washington associate professor of medicine, and supported by The Lustgarten Foundation, Canary Foundation, and other private sources........
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| Wed, 05 Mar 2008 00:20:43 GMT
| Blood Pressure Drugs Could Halt Pancreatic Cancer Spread
 Common blood pressure medications might help block the spread of pancreas cancer, scientists at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia have found. The researchers showed in laboratory studies that two types of pressure-lowering drugs - ACE inhibitors and AT1R blockers - may help reduce the development of tumor-feeding blood vessels, a process called angiogenesis. Such drugs, they say, may become part of a novel strategy to control the growth and spread of cancer........
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| Wed, 05 Mar 2008 00:20:43 GMT
| Smoking Related Cancers
 There are currently about fifty million smokers in the U.S. and there are another fifty million ex-smokers. Cigarette smoking has been linked to several human malignancies. Some of these links like the relationship between smoking and lung cancer are well established. In some other cases the relationship between smoking and cancer is not very well established. However several studies have clearly shown the malignant potential of chemical substances in cigarette smoke. This article is an attempt to summarize some of the known links between cigarette smoking and caner........
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| Wed, 05 Mar 2008 00:20:43 GMT
| Test To Predict Response In Pancreatic Cancer
 By slicing up bits of patient tumors and grafting them into mice, Johns Hopkins Kimmel Cancer Center specialists have figured out how to accurately "test drive" chemotherapy drugs to learn in advance which drug therapys offer each individual pancreas cancer patient the best therapeutic journey. Eventhough "xenografting" with either cells or fresh tissue is already used widely to test cancer therapies, the Hopkins design is personalized to each patient who has relapsed after an initial course of chemotherapy. "Eventually our approach offers a promising way to individualize treatment earlier in therapy instead of first giving everyone the standard drug gemcitabine, which has a success rate of less than 10 percent," says Antonio Jimeno, M.D., instructor in oncology at the Johns Hopkins Kimmel Cancer Center........
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